![]() “This was the first time since hiatus that got to hang out, talk stories, and just love and empower each other,” a source told Rolling Stone in May.įifth Harmony - responsible for hits like “Worth It,” “Work From Home,” “Down,” and “All in My Head (Flex)” - was formed on July 27, 2012, by Simon Cowell on the U.S. The news also comes after Dinah reunited with Jauregui and Brooke on separate occasions. Reunion has many meanings and while there's no official band reunion happening at the moment, some beautiful friendships and relationships are slowly reuniting in a healing and empowering way.įifth Harmony, last comprising Brooke, Normani, Jauregui, and Jane, announced an indefinite hiatus in 2018 to “pursue solo endeavors.” I'm thrilled to see there's a lot of interest surrounding Fifth Harmony. ( Camila Cabello is not part of the 5H partnership.) The news comes after Rolling Stone confirmed that the Fifth Harmony partnership - comprising Brooke, Dinah Jane, Lauren Jauregui, and Normani - received ownership of the group name’s trademark earlier this year, and after all five members celebrated the 10-year anniversary of Fifth Harmony’s formation last year. ![]() “Reunion has many meanings and while there’s no official band reunion happening at the moment, some beautiful friendships and relationships are slowly reuniting in a healing and empowering way.” “I’m thrilled to see there’s a lot of interest surrounding Fifth Harmony,” Brooke tweeted. The girls of Fifth Harmony aren’t officially reuniting, but Ally Brooke is rebuilding her relationship with fellow 5H members.Īfter a clip circulated online of Brooke agreeing that a reunion is “closer than we think” and that they are “maybe working on something,” the “Gone to Bed” singer clarified that she’s simply rekindling her relationship with the rest of 5H.
0 Comments
![]() The fact that every game I played I got a new high score, but then one to two moves after that achievement I was hit with something I clearly could not handle feels rigged. I feel like if you added a “here is your next three pieces” foresight, or made it so the algorithm will only ever give you one or even two of the same piece at a time, might be worth looking into in terms of balancing the system and not making players feel robbed of a good thing. ![]() You could be doing well, and preparing you board for something big, and then three of those blocks show up and there is nothing to do. ![]() The fact that at any point you can get three 9-block cubes at the same time and there is no way to predict or prepare for it is disappointing. Great concept, love the simplicity, but at a certain point the game becomes just a gamble. It would be a perfect opportunity to use my iTunes credit lol. Also, I personally find the ads a bit obnoxious, so I’d love an option to buy an ad-free version of the game. Thus, I’d really like to see an update in which the game doesn’t stop the player from beating their high score. I know one of the “helpful tips” is to “always leave room for more blocks” (Block Puzzle, 2021), but this is not always a possibility, or I was working on a bigger block to gain more points. However, the problem with this is that the game KNOWS I’m getting close and intentionally gives me pieces that may fit in my puzzle, but will not clear the way for the “gray” pieces that “won’t fit.” It’s quite infuriating as one time I was 20 points away from beating my high score (at the time, 2819, but it is currently 3140) but physically unable to destroy any more blocks. In my addiction to Block Puzzle and extensive hours playing the game, I’ve come to want to beat my high score each time. It’s so fun and the great thing is, it’s not timed and provides for a relaxing but brain-building activity. This game is so much fun and so addicting that I literally imagine shapes fitting into everyday spots (in my real life). ![]() The remaining blood components are returned to the patient along with a short-acting anticoagulant, such as citrate. This is done by passing venous blood through an extracorporeal blood centrifugal separation device, which allows for shunting of plasma for removal. Therapeutic plasma exchange (TPE) removes large-molecular-weight substances from patient plasma, including paraproteins, with the return of all cellular components to the patient. Despite the lack of randomized trials, this procedure rapidly reverses the clinical symptoms of hyperviscosity. Plasmapheresis has been used effectively for management of HVS associated with WM since the 1950's. ![]() Neurologic manifestations can range from relatively mild headache and lightheadedness to seizures and coma ( 4, 9, 15– 20). The most severe ophthalmologic manifestation of HVS is central retinal vein occlusion, which can result in irreversible vision loss and has been reported for patients with IgM and non-IgM paraproteinemias ( 14). Other ophthalmic findings may include flame hemorrhages, papilledema, exudates, and microaneurysms. Characteristic retinal vein dilation with tortuous “sausage link” appearance on retinal veins can be seen. Due to the high prevalence of ophthalmologic manifestations of HVS, a fundoscopic examination should be performed in any patient with suspected HVS or with a serum IgM > 3 g/dL. Ophthalmologic symptoms include blurred or double vision, retinal hemorrhage. Epistaxis is a common presenting symptom, and if present in a patient with a possible paraproteinemia, should prompt additional evaluation for HVS, particularly fundoscopic examination, as evidence of ocular HVS can be present without visual symptoms and is a treatment indication. Hemorrhage typically occurs in small venules associated with increased viscosity in areas with minimal supporting tissue, such as the nose and oral cavity. The predominant symptoms of HVS are mucocutaneous bleeding, ophthalmologic, and neurologic ( Table 1). Symptoms and Management of Hyperviscosity Syndrome It should be noted that, although the likelihood of HVS increases at higher levels of immunoglobulin, there is no discrete cutoff in any circumstance, and HVS should be considered for patients with characteristic symptoms and evidence of a paraprotein-secreting hematologic malignancy. Even in the context of a paraprotein-excreting hematologic malignancy, the risk of HVS is relatively low until the serum viscosity increases above 4 cP ( 9). IgG is relatively small (180 kDA) and can require levels as high as 10 g/dL to produce significant changes in viscosity, except for the IgG3 subtype, which has a tendency to aggregate and can increase viscosity at lower levels, perhaps due to its elongated hinge region and resultant increases in Fc-Fc interaction ( 9, 12, 13). IgA is smaller (320 kDA) than IgM but circulates as a dimer and is associated with increased viscosity at levels of 6 g/dL or greater ( 5, 11). IgM is pentameric and very large in size (970 kDA), and serum viscosity can increase significantly with IgM levels as low as 3 g/dL, and IgM levels of 6 g/dL or higher are associated with rapid development of hyperviscosity, with a median time to symptomatic HVS of 3 months ( 9, 10). Serum viscosity is correlated with immunoglobulin levels for patients both with and without monoclonal gammopathies ( 8), but the concentration of immunoglobulins required to significantly increase viscosity depends on the specific type of paraprotein. ![]() In contrast to most serum proteins, which are spherical in shape, immunoglobulins are relatively large but also linear in shape thus, when they travel through the serum, they spin around their longitudinal axis, increasing serum viscous drag, and therefore viscosity. The increased viscosity of serum relative to water relates primarily to its protein content. A typical serum viscosity for a healthy patient is 1.5 cP, or 1.7 relative to water. Viscosity can be measured in absolute terms in centipoise (cP), or in relative terms compared to the viscosity of water (0.894 cP). Paraprotein Levels and Hyperviscosity Syndrome HVS is a potentially life-threatening medical emergency that requires prompt recognition and intervention. HVS has also been recently reported in a patient with splenic marginal zone B cell lymphoma (IgM-κ) ( 7). It is most commonly observed in Waldenstrom macroglobulinemia (WM), affecting 10–30% of patients, and has been reported in 2–6% of patients with multiple myeloma ( 1– 6). Hyperviscosity syndrome (HVS) occurs in patients with hematological malignancies that secrete high levels of paraprotein (i.e, IgM, IgG, and IgA). Let’s look more closely at a few supporting features. ![]() The entry editing lifecycle is designed to provide authors clear, actionable information about the state of their content, and to prevent unintended loss. Stray drafts (those that were created but never edited or explicitly saved) are automatically garbage-collected, respecting the purgeUnsavedDraftsDuration setting.
![]() Its ability to unlock hidden settings, optimize performance, and customize the user interface makes it an indispensable tool for Mac enthusiasts, power users, and professionals alike. In conclusion, Koingo MacPilot is a powerful and user-friendly solution for Mac users seeking to take control of their macOS experience. Users can configure DNS settings, speed up network connections, and enhance privacy and firewall settings. These features contribute to a more organized and clutter-free Mac environment.Īdditionally, Koingo MacPilot offers tools for managing network settings, optimizing internet connectivity, and improving security. Koingo MacPilot provides tools for securely deleting files, managing file associations, and searching for duplicate files. The software’s advanced file management capabilities are also worth mentioning. This level of customization is invaluable for users who want their Mac to reflect their unique style and preferences. You can tweak settings related to the Dock, Finder, and system appearance, allowing you to personalize your Mac’s look and feel. This results in a faster, smoother, and more efficient Mac experience.Īnother noteworthy feature is the ability to customize and enhance the user interface. Users can access tools for clearing system and application caches, optimizing memory usage, and disabling or uninstalling unnecessary startup items. Koingo MacPilot also simplifies the process of managing and optimizing your Mac’s performance. ![]() This level of customization ensures that your Mac operates exactly as you desire. With Koingo MacPilot, you can delve into various categories of macOS settings, including system, file, network, and user interface settings, among others. The software’s user-friendly interface ensures that users of all technical levels can navigate its extensive feature set with ease. This means that users can fine-tune their Mac’s performance, appearance, and behavior according to their specific preferences. One of the standout features of Koingo MacPilot is its ability to provide users with access to advanced macOS settings that are typically hidden or challenging to access through the standard user interface. This application serves as a Swiss Army knife for Mac enthusiasts, offering an extensive array of features and functionalities to tweak, optimize, and customize their Mac experience. Koingo MacPilot is a comprehensive and versatile Mac software that empowers users to unlock the full potential of their macOS-powered devices. MacPilot is a comprehensive software application that you can use to enable and disable the hidden features of Mac in one click. Download MacPilot 15 for Mac full version program setup free. You can do this from the main database view or inside of a specific card. To create a relation between two databases, click + Add a property, then scroll through the property options until you find Relation. If you want to know what meal you ate after a particular workout, you would connect your Food Log to your Exercise Log using a relation. Say that you have a database called Exercise Log. This tells one database to pull in information from another database. You create a relational database by simply connecting two databases together using a property called relation. ![]() You can see which projects are connected to which clients and what contractors you hired for that project, or how much you need to bill a client for that project, and more - all in one place. Relational databases connect everything together. If you had a lot of organized spreadsheets next to each other that would be great, but in Notion your organized spreadsheets talk to each other. We have been big fans of Notion for a while now, and relational databases are what makes Notion, well Notion. Go to one of the databases you want to connect together and create a new property.What’s so great about relational databases? How to create a relation in a database Creating relations between items in the different databasesġ. What characters are parents or children to other characters.What groups experienced a particular historical event.What location a specific character comes from.What historical events a certain location has experienced.What characters are a part of a particular race or group.This allows storytellers to see things like: StoryFlint's World Building Bible Notion template uses relations between the different databases that store information about characters, locations, groups, historical events, etc. What characters have shared values they can bond with.If they're already using a specific archetype for one character to prevent using it on another character.What characters have personality traits that can conflict with or enable each other.What characters have similar personality types.These relations allow storytellers to easily see things like: StoryFlint's Ultimate Character Builder Notion template uses relations between its character list database and the various character attribute databases that help develop a character. and connect them together via relations.īelow are some examples of how StoryFlint has used relations in some Notion templates: Ultimate Character Builder You can create different databases for characters, scenes, chapters, locations, etc. Relations are a great way to organize and connect different elements of your story together. How can I use relations to organize my story in Notion? A tags database using relations to connect to an article database.A customers database using relations to connect to a products database.A projects database using relations to a tasks database. ![]() Relations are useful if you are using these kinds of databases Seeing if you need to find more recipes for a particular meat or cuisine.Seeing what recipes you have stored if you're wanting a particular cuisine.Seeing what recipes you can make with the meat you have.By adding relations, you can easily see how different database items are related to each other.Ĭonnecting data allows you to make more informed conclusions by seeing the aggregate data in different ways.įor example, in the home cooking databases, you can see how different recipes are related to specific meats and cuisines. Relation properties in Notion are great for making connections between disparate data. ![]() Why would I use relations to connect databases? |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |